A Different Way of Doing Things

by Birsoy, Kıvanç, Sabatini, David
Published 2018

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

by Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David
Published 2018

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc
Published 2017

DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

by Laplante, Mathieu, Horvat, Simon, Festuccia, William T., Birsoy, Kivanc, Prevorsek, Zala, Efeyan, Alejo, Sabatini, David M, Sabatini, David
Published 2014

A CRISPR screen identifies a pathway required for paraquat-induced cell death

by Reczek, Colleen R, Birsoy, Kıvanç, Kong, Hyewon, Martínez-Reyes, Inmaculada, Gao, Peng, Chandel, Navdeep S, Wang, Tim, Sabatini, David
Published 2018

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015

Identification and characterization of essential genes in the human genome

by Hughes, N. W., Wang, Tim, Birsoy, Kivanc, Krupczak, Kevin M., Post, Yorick, Lander, Eric Steven, Sabatini, David, Wei, Jenny J.
Published 2017

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

by Alvarez, Samantha W., Sviderskiy, Vladislav O., Terzi, Erdem M., Papagiannakopoulos, Thales, Moreira, Andre L., Adams, Sylvia, Birsoy, Kıvanç, Sabatini, David, Possemato, Richard
Published 2018

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

by Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary, Wang, Tim, Birsoy, Kivanc, Sabatini, David
Published 2015

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

by Chen, Walter W., Mihaylova, Maria M., Snitkin, Harriet, Stasinski, Iwona, Yucel, Burcu, Bayraktar, Erol C., Carette, Jan E., Clish, Clary, Brummelkamp, Thijn R., Sabatini, David M, Birsoy, Kivanc
Published 2015

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

by Bayraktar, Erol C., Baudrier, Lou, Özerdem, Ceren, Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Cangelosi, Andrew L., Sabatini, David M., Birsoy, Kıvanç, Chen, Walter W.
Published 2020

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

by Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary, Yilmaz, Omer, Peterson, Timothy Richard, Sabatini, David
Published 2013

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

by Lamming, Dudley W., Soliman, Mohamed A., Abdel Rahman, Anas M., Birsoy, Kivanc, Pawling, Judy, Frigolet, Maria E., Lu, Huogen, Fantus, I. George, Pasculescu, Adrian, Zheng, Yong, Dennis, James W., Pawson, Tony, Sabatini, David
Published 2015

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

by Katajisto, Pekka, Lamming, Dudley W., Gultekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zuckerberg, Lawrence, Bahn, Atul K., Deshpande, Vikram, Yilmaz, Omer, Sabatini, David
Published 2012

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

by Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

by Possemato, Richard, Marks, Kevin M., Kim, Dohoon, Birsoy, Kivanc, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing B., Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Shaul, Yoav, Pacold, Michael Edward, Sabatini, David
Published 2012