Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity
Signal transduction proteins are often multi-domain proteins that arose through the fusion of previously independent proteins. How such a change in the spatial arrangement of proteins impacts their evolution and the selective pressures acting on individual residues is largely unknown. We explored th...
| Main Authors: | , , , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Wiley Blackwell,
2014-04-11T19:17:33Z.
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| Subjects: | |
| Online Access: | Get fulltext |