High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function

High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function

The dissemination of HIV from an initial site of infection is facilitated by motile HIV-infected CD4+ T-cells. However, the impact of infected target cell migration on antigen recognition by HIV-specific CD8+ T-cells is unclear. Using a 3D in vitro model of tissue, we visualized dynamic interactions...

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Bibliographic Details
Main Authors: Foley, Maria Hottelet (Contributor), Forcier, Talitha L. (Contributor), McAndrew, Elizabeth G. (Author), Gonzalez, Michael (Author), Chen, Huabiao (Contributor), Juelg, Boris (Contributor), Walker, Bruce D. (Contributor), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-05-02T16:56:39Z.
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