Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Background: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible. Results: Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited ris...

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Main Authors: Karlsson, Elinor K (Author), Sigurdsson, Snaevar (Author), Ivansson, Emma (Author), Thomas, Rachael (Author), Elvers, Ingegerd (Author), Wright, Jason (Author), Howald, Cedric (Author), Tonomura, Noriko (Author), Perloski, Michele (Author), Swofford, Ross (Author), Biagi, Tara (Author), Fryc, Sarah (Author), Anderson, Nathan (Author), Courtay-Cahen, Celine (Author), Youell, Lisa (Author), Ricketts, Sally L. (Author), Mandlebaum, Sarah (Author), Rivera, Patricio (Author), von Euler, Henrik (Author), Kisseberth, William C. (Author), London, Cheryl A. (Author), Couto, Guillermo (Author), Starkey, Mike P. Comstock, Kenine (Author), Starkey, Mike P. (Author), Modiano, Jaime F. (Author), Breen, Matthew (Author), Lindblad-Toh, Kerstin (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2014-05-02T18:09:33Z.
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