End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts
A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1 : 1 molar ratio of the two starting material streams (chlorodiphenylmethane and N,N-dimethylaminoethanol) in the absence of additional solvent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry,
2014-05-21T20:56:47Z.
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| Subjects: | |
| Online Access: | Get fulltext |