End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts
A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1 : 1 molar ratio of the two starting material streams (chlorodiphenylmethane and N,N-dimethylaminoethanol) in the absence of additional solvent...
Main Authors: | Snead, David R. (Contributor), Jamison, Timothy F. (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry (Contributor) |
Format: | Article |
Language: | English |
Published: |
Royal Society of Chemistry,
2014-05-21T20:56:47Z.
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Subjects: | |
Online Access: | Get fulltext |
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