Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

Epithelial-mesenchymal transition (EMT) plays a critical role in the early stages of dissemination of carcinoma leading to metastatic tumors, which are responsible for over 90% of all cancer-related deaths. Current therapeutic regimens, however, have been ineffective in the cure of metastatic cancer...

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Main Authors: Aref, Amir R. (Contributor), Huang, Ruby Yun-Ju (Author), Yu, Weimiao (Author), Chua, Kian-Ngiap (Author), Sun, Wei (Author), Tu, Ting-Yuan (Author), Bai, Jing (Author), Sim, Wen-Jing (Author), Zervantonakis, Ioannis K. (Contributor), Thiery, Jean Paul (Author), Kamm, Roger Dale (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, 2014-06-09T17:22:36Z.
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