The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

The TGF-β/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall system is unknown. In this work, we used computational and experimental methods...

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Bibliographic Details
Main Authors: Wang, Junjie (Author), Tucker-Kellogg, Lisa (Author), Ng, Inn Chuan (Author), Jia, Ruirui (Author), Thiagarajan, P. S. (Author), White, Jacob K. (Contributor), Yu, Hanry (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-06-24T20:47:46Z.
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