KIR2DS4 Promotes HIV-1 Pathogenesis: New Evidence from Analyses of Immunogenetic Data and Natural Killer Cell Function

KIR2DS4 Promotes HIV-1 Pathogenesis: New Evidence from Analyses of Immunogenetic Data and Natural Killer Cell Function

Background: KIR2DS4 gene variants encode full-length and truncated protein products, with only the former serving as membrane-bound receptors to activate natural killer (NK) cells. We have previously shown that full-length KIR2DS4 was associated with relatively high viral load and accelerated hetero...

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Bibliographic Details
Main Authors: Merino, Aimee M. (Author), Dugast, Anne-Sophie (Author), Wilson, Craig M. (Author), Goepfert, Paul A. (Author), Alter, Galit (Contributor), Kaslow, Richard A. (Author), Tang, Jianming (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-07-08T16:58:47Z.
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