Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of MSC immunomodulatory function. This effect depends on signaling...

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Bibliographic Details
Main Authors: Ankrum, James Allen (Contributor), Dastidar, Riddhi G. (Author), Ong, Joon Faii (Author), Levy, Oren (Author), Karp, Jeffrey Michael (Contributor)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-07-09T15:04:09Z.
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