In Situ Analysis of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra

In Situ Analysis of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra

Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) as a major product. 8-oxodG is itself significantly more susceptible to oxidation than guanine, with the resulting damage consisting of more than 10 different products. This complexity has hampere...

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Bibliographic Details
Main Authors: Lim, Kok Seong (Contributor), Cui, Liang (Contributor), Taghizadeh, Koli (Contributor), Wishnok, John S. (Contributor), Chan, Wan Simon (Contributor), DeMott, Michael S. (Contributor), Babu, I. Ramesh (Contributor), Dedon, Peter C. (Contributor), Tannenbaum, Steven Robert (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2014-08-18T18:40:41Z.
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