Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis

Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis

As principal degrading enzymes of the extracellular matrix, metalloproteinases (MPs) contribute to various pathologies and represent a family of promising drug targets and biomarker candidates. However, multiple proteases and endogenous inhibitors interact to govern MP activity, often leading to hig...

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Bibliographic Details
Main Authors: Chen, Chia-Hung (Contributor), Sarkar, Aniruddh (Contributor), Beste, Michael T. (Contributor), Isaacson, Keith B. (Contributor), Lauffenburger, Douglas A. (Contributor), Griffith, Linda G. (Contributor), Han, Jongyoon (Contributor), Miller, Miles Aaron (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Gynepathology Research (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2014-08-19T20:35:22Z.
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