Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the inhibited receptor. To uncover common and unique fe...

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Bibliographic Details
Main Authors: Wagner, Joel Patrick (Contributor), Wolf-Yadlin, Alejandro (Author), Sevecka, Mark (Author), Grenier, Jennifer K. (Author), Root, David E. (Author), Lauffenburger, Douglas A. (Contributor), MacBeath, Gavin (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2014-08-20T16:41:10Z.
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