Direct observation of mammalian cell growth and size regulation

Direct observation of mammalian cell growth and size regulation

We introduce a microfluidic system for simultaneously measuring single-cell mass and cell cycle progression over multiple generations. We use this system to obtain over 1,000 h of growth data from mouse lymphoblast and pro-B-cell lymphoid cell lines. Cell lineage analysis revealed a decrease in the...

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Main Authors: Son, Sungmin (Contributor), Tzur, Amit (Author), Weng, Yaochung (Contributor), Jorgensen, Paul (Author), Kim, Jisoo (Contributor), Kirschner, Marc W. (Author), Manalis, Scott R (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Manalis, Scott R. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-08-21T15:47:03Z.
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