Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study

Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study

Objective: Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value for standard dosing is controversial. To evaluate the prediction of microdosing for active intracellular drug metabolites, we compared the PK...

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Main Authors: Chen, Jianmeng (Author), Flexner, Charles (Author), Liberman, Rosa G. (Contributor), Skipper, Paul L. (Contributor), Louissaint, Nicolette A. (Author), Hendrix, Craig W. (Author), Fuchs, Edward J. (Author), Tannenbaum, Steven Robert (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. School of Science (Contributor)
Format: Article
Language:English
Published: Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2014-08-26T15:28:59Z.
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