X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry
The 2-deoxy-scyllo-inosamine (DOIA) dehydrogenases are key enzymes in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. In contrast to most DOIA dehydrogenases, which are NAD-dependent, the DOIA dehydrogenase from Bacillus circulans (BtrN) is an S-adenosyl-l-methionine (A...
| Main Authors: | , , , |
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| Other Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences (U.S.),
2014-08-29T12:19:25Z.
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| Subjects: | |
| Online Access: | Get fulltext |