Searching for missing heritability: Designing rare variant association studies

Searching for missing heritability: Designing rare variant association studies

Genetic studies have revealed thousands of loci predisposing to hundreds of human diseases and traits, revealing important biological pathways and defining novel therapeutic hypotheses. However, the genes discovered to date typically explain less than half of the apparent heritability. Because effor...

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Main Authors: Zuk, Or (Author), Schaffner, Stephen F. (Author), Samocha, Kaitlin (Author), Do, Ron (Author), Hechter, Eliana (Author), Kathiresan, Sekar (Author), Daly, Mark J. (Author), Neale, Benjamin M. (Author), Sunyaev, Shamil R. (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-09-02T14:04:11Z.
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