Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC

Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide-MHC (pMHC), showing peptide specificity...

Full description

Bibliographic Details
Main Authors: Hoerter, John A. H. (Author), Brzostek, Joanna (Author), Artyomov, Maxim N. (Author), Abel, Steven M. (Contributor), Casas, Javier (Author), Rybakin, Vasily (Author), Ampudia, Jeanette (Author), Lotz, Carina (Author), Connolly, Janet M. (Author), Chakraborty, Arup K. (Contributor), Gould, Keith G. (Author), Gascoigne, Nicholas R. J. (Author)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2014-09-02T14:15:31Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items