The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia (T-ALL) and initiates T-ALL in mouse models. By performing global microRNA (miRNA) expression profiling after depletion of TAL1, together with genome-wide analysis of TAL1...

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Main Authors: Mansour, Marc R. (Author), Sanda, Takaomi (Author), Lawton, Lee N. (Author), Li, Xiaoyu (Author), Kreslavsky, Taras (Author), Novina, Carl D. (Author), Brand, Marjorie (Author), Gutierrez, Alejandro (Author), Kelliher, Michelle A. (Author), Jamieson, Catriona H. M. (Author), von Boehmer, Harald (Author), Young, Richard A. (Contributor), Look, A. Thomas (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2014-09-02T14:30:25Z.
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