In vivo discovery of immunotherapy targets in the tumour microenvironment

In vivo discovery of immunotherapy targets in the tumour microenvironment

Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced disease. However, the regulatory switches controlling T-cell function in immunosuppressive tumours are not well understood. Here we show that suc...

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Main Authors: Zhou, Penghui (Author), Shaffer, Donald R. (Author), Alvarez Arias, Diana A. (Author), Nakazaki, Yukoh (Author), Pos, Wouter (Author), Torres, Alexis J. (Contributor), Cremasco, Viviana (Author), Dougan, Stephanie K. (Contributor), Cowley, Glenn S. (Author), Elpek, Kutlu (Author), Brogdon, Jennifer (Author), Lamb, John (Author), Turley, Shannon J. (Author), Ploegh, Hidde (Contributor), Root, David E. (Author), Dranoff, Glenn (Author), Hacohen, Nir (Author), Cantor, Harvey (Author), Wucherpfennig, Kai W. (Author), Love, John C (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Love, J. Christopher (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-09-03T19:44:21Z.
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