Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice

Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b[superscript −/−]) suggest that hepatic PTP1b inhibition would mitigate metabolic-syndro...

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Main Authors: Miraldi, Emily Rae (Contributor), Sharfi, Hadar (Contributor), Friedline, Randall H. (Author), Johnson, Hannah (Contributor), Zhang, Tejia (Author), Lau, Ken S. (Contributor), Ko, Hwi Jin (Author), Curran, Timothy G. (Contributor), Haigis, Kevin M. (Author), Yaffe, Michael B. (Contributor), Bonneau, Richard (Author), Lauffenburger, Douglas A. (Contributor), Kahn, Barbara B. (Author), Kim, Jason K. (Author), Neel, Benjamin G. (Author), Saghatelian, Alan (Author), White, Forest M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, 2014-09-04T18:50:36Z.
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