Genome-Wide Prediction and Validation of Peptides That Bind Human Prosurvival Bcl-2 Proteins

Genome-Wide Prediction and Validation of Peptides That Bind Human Prosurvival Bcl-2 Proteins

Programmed cell death is regulated by interactions between pro-apoptotic and prosurvival members of the Bcl-2 family. Pro-apoptotic family members contain a weakly conserved BH3 motif that can adopt an alpha-helical structure and bind to a groove on prosurvival partners Bcl-x[subscript L], Bcl-w, Bc...

Full description

Bibliographic Details
Main Authors: Taipale, Mikko (Contributor), Keating, Amy E. (Contributor), DeBartolo, Joseph Vincent (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-09-09T14:11:43Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items