Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated...

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Main Authors: Sasaki, Tomoyuki (Author), Lian, Shanshan (Author), Qi, Jie (Author), Bayliss, Peter E. (Author), Carr, Christopher E. (Contributor), Johnson, Jennifer L. (Author), Guha, Sujay (Author), Kobler, Patrick (Author), Catz, Sergio D. (Author), Gill, Matthew (Author), Jia, Kailiang (Author), Klionsky, Daniel J. (Author), Kishi, Shuji (Author)
Other Authors: Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-09-09T16:17:35Z.
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