Mutator/Hypermutable Fetal/Juvenile Metakaryotic Stem Cells and Human Colorectal Carcinogenesis

Mutator/Hypermutable Fetal/Juvenile Metakaryotic Stem Cells and Human Colorectal Carcinogenesis

Adult age-specific colorectal cancer incidence rates increase exponentially from maturity, reach a maximum, then decline in extreme old age. Armitage and Doll (1) postulated that the exponential increase resulted from "n" mutations occurring throughout adult life in normal "cells at r...

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Main Authors: Kini, Lohith G. (Contributor), Herrero-Jimenez, Pablo (Author), Sanghvi, Jayodita (Author), Gutierrez, Efren (Author), Kusko, Rebecca (Author), Rexer, Karl (Author), Kurzweil, Ray (Author), Refinetti, Paulo (Author), Morgenthaler, Stephan (Author), Gostjeva, Elena V. (Contributor), Kamath, Tushar V. (Contributor), Hensle, David 1981- (Author), Kogel, John 1981- (Author), Koledova, Vera V (Author), Thilly, William G (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koledova, Vera V. (Contributor), Thilly, William G. (Contributor)
Format: Article
Language:English
Published: Frontiers Research Foundation, 2014-09-10T16:18:13Z.
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