Mutator/Hypermutable Fetal/Juvenile Metakaryotic Stem Cells and Human Colorectal Carcinogenesis
Adult age-specific colorectal cancer incidence rates increase exponentially from maturity, reach a maximum, then decline in extreme old age. Armitage and Doll (1) postulated that the exponential increase resulted from "n" mutations occurring throughout adult life in normal "cells at r...
Main Authors: | , , , , , , , , , , , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Frontiers Research Foundation,
2014-09-10T16:18:13Z.
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Subjects: | |
Online Access: | Get fulltext |