A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

Herpes simplex virus (HSV) utilizes and subverts host chromatin mechanisms to express its lytic gene products in mammalian cells. The host cell attempts to silence the incoming viral genome by epigenetic mechanisms, but the viral VP16 and ICP0 proteins promote active chromatin on the viral genome by...

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Bibliographic Details
Main Authors: Oh, Hyung Suk (Author), Bryant, Kevin F. (Author), Nieland, Thomas J. (Author), Mazumder, Aprotim (Contributor), Bagul, Mukta (Author), Bathe, Mark (Contributor), Root, David E. (Author), Knipe, David M. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Laboratory for Computational Cell Biology & Biophysics (Contributor)
Format: Article
Language:English
Published: American Society for Microbiology, 2014-09-16T15:59:08Z.
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