SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

The epithelial-to-mesenchymal transition (EMT) is important for the development of cancer metastases and organ fibrosis, conditions prevalent in aging. Because sirtuins affect the pathology of aging, we tested the effect of SirT1 on EMT. Reduced SIRT1 levels in HMLER breast cancer cells led to incre...

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Bibliographic Details
Main Authors: Simic, Petra (Contributor), Williams, Eric O (Author), Bell, Eric L. (Contributor), Gong, Jing Jing (Contributor), Bonkowski, Michael S. (Contributor), Guarente, Leonard Pershing (Contributor), Williams, Eric O. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-09-24T16:32:05Z.
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