Mechanotransduction of fluid stresses governs 3D cell migration

Mechanotransduction of fluid stresses governs 3D cell migration

Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from the tumor core. Tumor-associated interstitial flow (IF) at a rate of ∼3 µm/s has been shown to induce cell migration in the upstream direction (rheotaxis). However, the molecular biophysical mechanism...

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Bibliographic Details
Main Authors: Polacheck, William J. (Contributor), German, Alexandra E. (Contributor), Mammoto, Akiko (Author), Ingber, Donald E. (Author), Kamm, Roger Dale (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-09-24T19:34:36Z.
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