Splice isoform and pharmacological studies reveal that sterol depletion relocalizes -synuclein and enhances its toxicity
Synucleinopathies are neurodegenerative diseases associated with toxicity of the lipid-binding protein α-synuclein (α-syn). When expressed in yeast, α-syn associates with membranes at the endoplasmic reticulum and traffics with vesicles out to the plasma membrane. At higher levels it elicits a numbe...
| Main Authors: | , , |
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| Other Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences (U.S.),
2014-09-25T18:36:28Z.
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| Subjects: | |
| Online Access: | Get fulltext |