Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates

Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates

Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an activatable immunoconjugate. The immunoconjugate is composed of self-quenching, near-i...

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Bibliographic Details
Main Authors: Spring, Bryan Q. (Author), Abu-Yousif, Adnan O. (Author), Palanisami, Akilan (Author), Rizvi, Imran (Author), Zheng, Xiang (Author), Mai, Zhiming (Author), Anbil, Sriram (Author), Sears, R. Bryan (Author), Mensah, Lawrence B. (Author), Goldschmidt, Ruth (Author), Erdem, S. Sibel (Author), Oliva, Esther (Author), Hasan, Tayyaba (Contributor)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-09-25T18:52:45Z.
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