A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo

A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo

A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) in vivo. The stress-activated p38 mitogen-activated...

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Bibliographic Details
Main Authors: Reinhardt, H. Christian (Author), Kim, Jacob S (Author), Ruf, Daniela M (Author), Mitra, Tanya (Contributor), Couvillon, Anthony D (Author), Yaffe, Michael B (Author), Cannell, Ian Gordon (Contributor), Reinhardt, H. Christian (Contributor), Kim, Jacob S. (Contributor), Ruf, Daniela M. (Contributor), Morandell, Sandra M. (Author), Jacks, Tyler E (Author), Yaffe, Michael B (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Morandell, Sandra (Contributor), Jacks, Tyler E. (Contributor), Yaffe, Michael B. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-10-02T18:43:04Z.
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