Site-Specific Chemoenzymatic Labeling of Aerolysin Enables the Identification of New Aerolysin Receptors

Site-Specific Chemoenzymatic Labeling of Aerolysin Enables the Identification of New Aerolysin Receptors

Aerolysin is a secreted bacterial toxin that perforates the plasma membrane of a target cell with lethal consequences. Previously explored native and epitope-tagged forms of the toxin do not allow site-specific modification of the mature toxin with a probe of choice. We explore sortase-mediated tran...

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Bibliographic Details
Main Authors: Wuethrich, Irene (Contributor), Peeters, Janneke G. C. (Contributor), Blom, Annet E. M. (Contributor), Theile, Christopher S. (Contributor), Li, Zeyang (Contributor), Spooner, Eric (Contributor), Ploegh, Hidde (Contributor), Guimaraes, Carla P. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-10-15T18:52:26Z.
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