Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

The specific activation of Toll-like receptors (TLRs) has potential utility for a variety of therapeutic indications including antiviral immunotherapy and as vaccine adjuvants. TLR7 and TLR 8 may be activated by their native ligands, single-stranded RNA, or by small molecules of the imidazoquinoline...

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Bibliographic Details
Main Authors: Nguyen, David N. (Contributor), Mahon, Kerry P. (Contributor), Chikh, Ghania (Author), Kim, Phillip (Contributor), Chung, Hattie (Contributor), Vicari, Alain P. (Author), Love, Kevin T. (Contributor), Goldberg, Michael Solomon (Contributor), Chen, Steve (Contributor), Krieg, Arthur M. (Author), Chen, Jianzhu (Contributor), Langer, Robert (Contributor), Anderson, Daniel Griffith (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-10-21T16:21:16Z.
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