Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short interfering RNA (siRNA) delivered in lipid nanoparticles (LNPs) using cellular...

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Bibliographic Details
Main Authors: Sahay, Gaurav (Contributor), Querbes, William (Author), Alabi, Christopher A. (Contributor), Eltoukhy, Ahmed A. (Contributor), Sarkar, Sovan (Author), Zurenko, Christopher (Author), Karagiannis, Emmanouil (Contributor), Love, Kevin T. (Contributor), Chen, Delai (Contributor), Zoncu, Roberto (Author), Buganim, Yosef (Author), Schroeder, Avi (Contributor), Langer, Robert (Contributor), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: 2014-10-30T19:26:33Z.
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