Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

Enhanced signaling by the small guanosine triphosphatase Ras is common in T cell acute lymphoblastic leukemia/lymphoma (T-ALL), but the underlying mechanisms are unclear. We identified the guanine nucleotide exchange factor RasGRP1 (Rasgrp1 in mice) as a Ras activator that contributes to leukemogene...

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Main Authors: Yang, Ming (Contributor), Govern, Christopher C. (Contributor), Chakraborty, Arup K. (Contributor), Hartzell, Catherine (Author), Ksionda, Olga (Author), Lemmens, Ed (Author), Coakley, Kristen (Author), Dail, Monique (Author), Harvey, Richard C. (Author), Bakker, Jeroen (Author), Lenstra, Tineke L. (Author), Ammon, Kristin (Author), Boeter, Anne (Author), Winter, Stuart S. (Author), Loh, Mignon (Author), Shannon, Kevin (Author), Wabl, Matthias (Author), Roose, Jeroen P. (Author)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2014-11-03T14:39:03Z.
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