Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/...

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Main Authors: Dong, Yizhou (Contributor), Love, Kevin T. (Contributor), Dorkin, Joseph Robert (Contributor), Sirirungruang, Sasilada (Contributor), Zhang, Yunlong (Contributor), Chen, Delai (Contributor), Bogorad, Roman (Contributor), Yin, Hao (Contributor), Chen, Yi (Contributor), Vegas, Arturo (Contributor), Alabi, Christopher A. (Contributor), Sahay, Gaurav (Contributor), Olejnik, Karsten (Contributor), Wang, Weiheng (Contributor), Schroeder, Avi (Contributor), Lytton-Jean, Abigail K. R. (Contributor), Siegwart, Daniel J. (Contributor), Akinc, Akin (Author), Barnes, Carmen (Author), Barros, Scott A. (Author), Carioto, Mary (Author), Fitzgerald, Kevin (Author), Hettinger, Julia (Author), Kumar, Varun (Author), Novobrantseva, Tatiana I. (Author), Qin, June (Author), Querbes, William (Author), Kotelianski, Victor E. (Author), Langer, Robert (Contributor), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-11-05T20:15:35Z.
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