Modular 'Click-in-Emulsion' Bone-Targeted Nanogels
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand r...
Main Authors: | , , , , , , , , , , , , , , , , |
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Other Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Published: |
Wiley Blackwell,
2014-11-07T13:31:27Z.
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Subjects: | |
Online Access: | Get fulltext |
Summary: | A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects. National Institutes of Health (U.S.) (RO1 DE016516) National Institutes of Health (U.S.) (R01 EB000244) Damon Runyon Cancer Research Foundation (DFS-#2050-10) |
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