Modular 'Click-in-Emulsion' Bone-Targeted Nanogels

• Main Authors: Heller, Daniel A. (Contributor), Levi, Yair (Contributor), Wallas, Jasmine (Contributor), Pratt, George W. (Contributor), Jiang, Shan (Contributor), Sahay, Gaurav (Contributor), Schroeder, Josh E. (Author), Chyan, Yieu (Contributor), Zurenko, Christopher (Author), Querbes, William (Author), Manzano, Miguel (Contributor), Kohane, Daniel S. (Author), Anderson, Daniel Griffith (Contributor), Pelet, Jeisa (Author), Doloff, Joshua C (Author), Schroeder, Avraham Dror (Author), Langer, Robert S (Author)
• Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Pelet, Jeisa M. (Contributor), Doloff, Joshua C. (Contributor), Schroeder, Avi (Contributor), Langer, Robert (Contributor)
• Format: Article
• Language: English
• Published: Wiley Blackwell, 2014-11-07T13:31:27Z.
• Subjects: Article
• Online Access: Get fulltext

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
National Institutes of Health (U.S.) (RO1 DE016516)
National Institutes of Health (U.S.) (R01 EB000244)
Damon Runyon Cancer Research Foundation (DFS-#2050-10)