Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading to potential adverse events and safety concerns. We have developed a synthetic...

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Main Authors: Ilyinskii, Petr O. (Author), Roy, Christopher J. (Author), O'Neil, Conlin P. (Author), Browning, Erica A. (Author), Pittet, Lynnelle A. (Author), Altreuter, David H. (Author), Alexis, Frank (Author), Tonti, Elena (Author), Shi, Jinjun (Author), Basto, Pamela Antonia (Contributor), Iannacone, Matteo (Author), Radovic-Moreno, Aleksandar F. (Contributor), Farokhzad, Omid C. (Author), von Andrian, Ulrich H. (Author), Johnston, Lloyd P. M. (Author), Kishimoto, Takashi Kei (Author), Langer, Robert (Contributor)
Other Authors: Harvard University- (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-07T15:50:17Z.
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