Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated...

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Bibliographic Details
Main Authors: Gianella, Anita (Author), Mieszawska, Aneta J. (Author), Hoeben, Freek J. M. (Author), Janssen, Henk M. (Author), Jarzyna, Peter A. (Author), Cormode, David P. (Author), Costa, Kevin D. (Author), Rao, Satish (Author), Farokhzad, Omid C. (Author), Langer, Robert (Contributor), Fayad, Zahi A. (Author), Mulder, Willem J. M. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, 2014-11-07T16:12:07Z.
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