Histone Deacetylase 5 Limits Cocaine Reward through cAMP-Induced Nuclear Import

Histone Deacetylase 5 Limits Cocaine Reward through cAMP-Induced Nuclear Import

Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulate...

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Bibliographic Details
Main Authors: Taniguchi, Makoto (Author), Carreira, Maria B (Author), Smith, Laura N (Author), Zirlin, Benjamin C (Author), Neve, Rachael L. (Contributor), Cowan, Christopher W (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-12T13:29:58Z.
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