Histone Deacetylase 5 Limits Cocaine Reward through cAMP-Induced Nuclear Import
Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulate...
Main Authors: | , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2014-11-12T13:29:58Z.
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Subjects: | |
Online Access: | Get fulltext |