The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells. Importantl...

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Bibliographic Details
Main Authors: Zwaans, Bernadette M.M (Author), Silberman, Dafne M (Author), Goren, Alon (Author), Zhong, Lei (Author), Ram, Oren (Author), Truelove, Jessica (Author), Guimaraes, Alexander R. (Author), Toiber, Debra (Author), Cosentino, Claudia (Author), Greenson, Joel K (Author), MacDonald, Alasdair I (Author), McGlynn, Liane (Author), Maxwell, Fraser (Author), Edwards, Joanne (Author), Giacosa, Sofia (Author), Guccione, Ernesto (Author), Weissleder, Ralph (Author), Bernstein, Bradley E. (Contributor), Regev, Aviv (Contributor), Shiels, Paul G (Author), Lombard, David B. (Author), Mostoslavsky, Raul (Author), Sebastian, Carlos (Author), Gymrek, Melissa A. (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-12T13:47:30Z.
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