Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its re...

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Main Authors: Sanda, Takaomi (Author), Lawton, Lee N. (Author), Barrasa, M. Inmaculada (Author), Fan, Zi Peng (Contributor), Kohlhammer, Holger (Author), Gutierrez, Alejandro (Author), Ma, Wenxue (Author), Tatarek, Jessica (Author), Ahn, Yebin (Author), Kelliher, Michelle A. (Author), Jamieson, Catriona H. M. (Author), Staudt, Louis M (Author), Young, Richard A (Author), Look, A. Thomas (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Young, Richard A. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-13T18:38:32Z.
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