Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamell...

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Bibliographic Details
Main Authors: Van Lehn, Reid C. (Contributor), Atukorale, Prabhani U. (Contributor), Carney, Randy P. (Author), Yang, Yu-Sang Sabrina (Contributor), Stellacci, Francesco (Author), Irvine, Darrell J. (Contributor), Alexander-Katz, Alfredo (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2014-11-20T14:24:52Z.
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