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91636 |
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|a Van Lehn, Reid C.
|e author
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|a Massachusetts Institute of Technology. Department of Biological Engineering
|e contributor
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|a Massachusetts Institute of Technology. Department of Materials Science and Engineering
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Van Lehn, Reid C.
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|a Yang, Yu-Sang Sabrina
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|a Irvine, Darrell J.
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|a Alexander-Katz, Alfredo
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|a Atukorale, Prabhani U.
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|a Atukorale, Prabhani U.
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|a Carney, Randy P.
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|a Yang, Yu-Sang Sabrina
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|a Stellacci, Francesco
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|a Irvine, Darrell J.
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|a Alexander-Katz, Alfredo
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|a Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers
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|b American Chemical Society (ACS),
|c 2014-11-20T14:24:52Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/91636
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|a Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
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|a National Science Foundation (U.S.). Graduate Research Fellowship Program
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|a National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (Award DMR-0819762)
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|a National Cancer Institute (U.S.) (Award U54CA143874)
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|a United States. Army Research Office (Contract W911NF-13-D-0001)
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|a United States. Army Research Office (Contract W911NF-07-D-0004, T.O. 8)
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|a en_US
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|a Article
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|t Nano Letters
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