A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging agent doxorubicin. A critical challenge for translating this therapeutic network...

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Main Authors: Morton, Stephen Winford (Contributor), Lee, Michael J. (Contributor), Deng, Zhou J. (Contributor), Siouve, Elise (Contributor), Shopsowitz, Kevin (Contributor), Shah, Nisarg J. (Contributor), Dreaden, Erik (Author), Yaffe, Michael B (Author), Hammond, Paula T (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Dreaden, Erik Christopher (Contributor), Yaffe, Michael B. (Contributor), Hammond, Paula T. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2014-11-21T20:28:45Z.
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