Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing

Retrotransposons constitute a major source of genetic variation, and somatic retrotransposon insertions have been reported in cancer. Here, we applied TranspoSeq, a computational framework that identifies retrotransposon insertions from sequencing data, to whole genomes from 200 tumor/normal pairs a...

Full description

Bibliographic Details
Main Authors: Helman, Elena (Contributor), Lawrence, Michael S. (Author), Stewart, Chip (Author), Sougnez, Carrie (Author), Getz, Gad (Author), Meyerson, Matthew L. (Author)
Other Authors: Harvard University- (Contributor), Meyerson, Matthew (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2014-12-02T17:01:44Z.
Subjects:
Online Access:Get fulltext