Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

Most archaea and bacteria use a modified C in the anticodon wobble position of isoleucine tRNA to base pair with A but not with G of the mRNA. This allows the tRNA to read the isoleucine codon AUA without also reading the methionine codon AUG. To understand why a modified C, and not U or modified U,...

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Bibliographic Details
Main Authors: Mandal, Debabrata (Contributor), Koehrer, Caroline (Contributor), Su, Dan (Contributor), Babu, I. Ramesh (Contributor), Chan, Tsz Yan Clement (Contributor), Liu, Yuchen (Author), Soll, Dieter (Author), Blum, Paul (Author), Kuwahara, Masayasu (Author), Dedon, Peter C. (Contributor), Rajbhandary, Uttam L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press/RNA Society, 2014-12-02T17:26:22Z.
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