Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated polymorphisms contribute to pathogenesis have been difficult to dissect gi...

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Main Authors: Lassen, Kara G. (Author), Kuballa, Petric (Author), Conway, Kara L. (Author), Patel, Khushbu (Author), Becker, Christine E. (Author), Peloquin, Joanna M. (Author), Villablanca, Eduardo J. (Author), Norman, Jason M. (Author), Liu, Ta-Chung (Author), Heath, Robert J. W. (Author), Becker, Morgan L. (Author), Fagbami, Lola (Author), Horn, Heiko (Author), Mercer, Johnathan (Author), Yilmaz, Omer (Contributor), Jaffe, Jacob D. (Author), Shamji, Alykhan F. (Author), Bahn, Atul K. (Author), Carr, Steven A. (Author), Daly, Mark J. (Author), Virgin, Herbert W. (Author), Schreiber, Stuart L. (Author), Stappenbeck, Thaddeus S. (Author), Xavier, Ramnik J. (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-12-02T18:42:05Z.
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