The Lin28/let-7 Axis Regulates Glucose Metabolism

The Lin28/let-7 Axis Regulates Glucose Metabolism

The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating metabolism. When overexpressed in mice, both Lin28...

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Main Authors: Zhu, Hao (Author), Shyh-Chang, Ng (Author), Segrè, Ayellet V (Author), Shinoda, Gen (Author), Shah, Samar P (Author), Einhorn, William S. (Author), Takeuchi, Ayumu (Author), Engreitz, Jesse Michael (Contributor), Hagan, John P. (Author), Kharas, Michael G. (Author), Urbach, Achia (Author), Thornton, James E. (Author), Triboulet, Robinson (Author), Gregory, Richard I. (Author), Altshuler, David (Author), Daley, George Q. (Author)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2014-12-02T19:07:42Z.
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